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TargetL-lactate dehydrogenase A
LigandBDBM86117
Substrate/Competitorn/a
Meas. Tech.Surface Plasmon Resonance (SPR) Assay
pH7.4±0
Kd 7.70e+5± 0 nM
Citation Ward RABrassington CBreeze ALCaputo ACritchlow SDavies GGoodwin LHassall GGreenwood RHoldgate GAMrosek MNorman RAPearson STart JTucker JAVogtherr MWhittaker DWingfield JWinter JHudson K Design and synthesis of novel lactate dehydrogenase a inhibitors by fragment-based lead generation. J Med Chem 55:3285-306 (2012) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
L-lactate dehydrogenase A
Name:L-lactate dehydrogenase A
Synonyms:L-lactate dehydrogenase A chain
Type:Protein
Mol. Mass.:36456.12
Organism:Rattus norvegicus (Rat)
Description:P04642::PDB Codes: 4ajl, 4aj2, 4aje, 4aji, 4ajk, 4ajh, 4ajl, 4al4, 4ajh, 4ajo
Residue:332
Sequence:
MAALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGI
SDVVKVTLTPDEEARLKKSADTLWGIQKELQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM86117
NameBDBM86117
Synonyms:LDHA Inhibitor, 12
TypeSmall organic molecule
Emp. Form.C10H11N3OS
Mol. Mass.221.279
SMILESCNc1nc2ccc(NC(C)=O)cc2s1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a