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TargetCathepsin L1
LigandBDBM50390404
Substrate/Competitorn/a
Meas. Tech.ChEMBL_834956
IC50>100000±n/a nM
Citation Dossetter AGBowyer JCook CRCrawford JJFinlayson JEHeron NMHeyes CHighton AJHudson JAJestel AKrapp SMacFaul PAMcGuire TMMorley ADMorris JJPage KMRibeiro LRSawney HSteinbacher SSmith C Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition. Bioorg Med Chem Lett 22:5563-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50390404
NameBDBM50390404
Synonyms:CHEMBL2070936
TypeSmall organic molecule
Emp. Form.C22H27FN4O2
Mol. Mass.398.4738
SMILESFc1ccc(cc1)N1CCN(CC1)C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(CC1)C#N |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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