Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCarbonic anhydrase
LigandBDBM50377332
Substrate/Competitorn/a
Meas. Tech.ChEMBL_479524
Ki 128±n/a nM
Citation Cecchi ACiani LWinum JYMontero JLScozzafava ARistori SSupuran CT Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes. Bioorg Med Chem Lett 18:3475-80 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase
Name:Carbonic anhydrase
Synonyms:CA-I | CAB | Carbonate dehydratase I | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA I
Type:Enzyme
Mol. Mass.:28873.37
Organism:Homo sapiens (human)
Description:P00915
Residue:261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50377332
NameBDBM50377332
Synonyms:CHEMBL436648
TypeSmall organic molecule
Emp. Form.C16H24ClN4O3S2
Mol. Mass.419.97
SMILESCC1(C)CC(CC(C)(C)N1[O])NC(=S)Nc1ccc(cc1Cl)S(N)(=O)=O |^1:10|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a