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TargetPTK2B protein tyrosine kinase 2 beta (PTK2B)
LigandBDBM50246327
Substrate/Competitorn/a
Meas. Tech.ChEMBL_558214
IC50 154±n/a nM
Citation Walker DPBi FCKalgutkar ASBauman JNZhao SXSoglia JRAspnes GEKung DWKlug-McLeod JZawistoski MPMcGlynn MAOliver RDunn MLi JCRichter DTCooper BAKath JCHulford CAAutry CLLuzzio MJUng EJRoberts WGBonnette PCBuckbinder LMistry AGriffor MCHan SGuzman-Perez A Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation. Bioorg Med Chem Lett 18:6071-7 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
PTK2B protein tyrosine kinase 2 beta (PTK2B)
Name:PTK2B protein tyrosine kinase 2 beta (PTK2B)
Synonyms:PTK2B | PTK2B protein tyrosine kinase 2 beta | Protein tyrosine kinase 2 beta
Type:Protein
Mol. Mass.:115868.80
Organism:Homo sapiens (Human)
Description:Q14289
Residue:1009
Sequence:
MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50246327
NameBDBM50246327
Synonyms:4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzenesulfonamide | 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide | CHEMBL509485
TypeSmall organic molecule
Emp. Form.C19H25F3N6O2S
Mol. Mass.458.501
SMILESCNS(=O)(=O)c1ccc(Nc2ncc(c(N[C@@H]3CCC[C@H]3N(C)C)n2)C(F)(F)F)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a