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TargetGlucocerebrosidase (Acid beta-Glucosidase)
LigandBDBM42355
Substrate/Competitorn/a
Meas. Tech.Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity
EC50>50000±n/a nM
Citation PubChem PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay (2008)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Glucocerebrosidase (Acid beta-Glucosidase)
Name:Glucocerebrosidase (Acid beta-Glucosidase)
Synonyms:β-glucocerebrosidase (GCase) | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase). | Imiglucerase
Type:Enzyme
Mol. Mass.:59724.64
Organism:Homo sapiens (human)
Description:The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM42355
n/a
NameBDBM42355
Synonyms:3-(2,1,3-benzothiadiazol-4-ylsulfonylamino)-N-(1-benzylpiperidin-4-yl)propanamide | 3-(2,1,3-benzothiadiazol-4-ylsulfonylamino)-N-[1-(phenylmethyl)-4-piperidinyl]propanamide | 3-(2,1,3-benzothiadiazol-4-ylsulfonylamino)-N-[1-(phenylmethyl)piperidin-4-yl]propanamide | MLS000044398 | N-(1-benzyl-4-piperidyl)-3-(piazthiol-4-ylsulfonylamino)propionamide | N~3~-(2,1,3-benzothiadiazol-4-ylsulfonyl)-N~1~-(1-benzylpiperidin-4-yl)-beta-alaninamide | SMR000022175 | cid_3242583
TypeSmall organic molecule
Emp. Form.C21H25N5O3S2
Mol. Mass.459.585
SMILESO=C(CCNS(=O)(=O)c1cccc2nsnc12)NC1CCN(Cc2ccccc2)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: