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TargetGeranylgeranyl Diphosphate Synthase (GGPPS)
LigandBDBM12577
Substrate/CompetitorBDBM25257
Meas. Tech.GGPP Synthase Inhibition Assay
IC50 79430±n/a nM
Citation K-M Chen CHudock MPZhang YGuo RTCao RNo JHLiang PHKo TPChang THChang SCSong YAxelson JKumar AWang AHOldfield E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem 51:5594-607 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Geranylgeranyl Diphosphate Synthase (GGPPS)
Name:Geranylgeranyl Diphosphate Synthase (GGPPS)
Synonyms:Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPSase | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:Homooctamer; transferase
Mol. Mass.:34867.94
Organism:Homo sapiens (human)
Description:Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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  Blast E-value cutoff:
BDBM12577
BDBM25257
NameBDBM12577
Synonyms:Bisphosphonate 2 | CHEMBL997 | JMC515594 Compound 53 | {1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl}phosphonic acid
TypeSmall organic molecule
Emp. Form.C9H23NO7P2
Mol. Mass.319.2289
SMILESCCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O
Structure
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