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TargetLeukotriene A4 hydrolase
LigandBDBM24277
Substrate/CompetitorBDBM23991
Meas. Tech.Peptidase Assay
IC50 17±n/a nM
Citation Kirkland TAAdler MBauman JGChen MHaeggström JZKing BKochanny MJLiang AMMendoza LPhillips GBThunnissen MTrinh LWhitlow MYe BYe HParkinson JGuilford WJ Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem 16:4963-83 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Leukotriene A4 hydrolase
Name:Leukotriene A4 hydrolase
Synonyms:LTA-4 hydrolase | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H)
Type:Hydrolase; metalloprotease
Mol. Mass.:69280.41
Organism:Homo sapiens (human)
Description:Human recombinant LTA4H.
Residue:611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM24277
NameBDBM24277
Synonyms:(2S)-2-amino-4-{[4-(2-hydroxy-2-phenylethoxy)phenyl]carbamoyl}butanoic acid | Modified amino acid analog, 8l
TypeSmall organic molecule
Emp. Form.C19H22N2O5
Mol. Mass.358.3884
SMILESN[C@@H](CCC(=O)Nc1ccc(OCC(O)c2ccccc2)cc1)C(O)=O |r|
Structure
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BDBM23991
NameBDBM23991
Synonyms:(2S)-2-amino-N-(4-nitrophenyl)propanamide | Ala-4-nitroanilide | Alanine para-nitroanilide | L-Alanine-4-nitroanilide
Typen/a
Emp. Form.C9H11N3O3
Mol. Mass.209.2019
SMILESC[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: