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TargetOrotidine Monophosphate Decarboxylase (ODCase)
LigandBDBM21338
Substrate/CompetitorBDBM21336
Meas. Tech.Enzyme Inhibition Assay
pH7.5±n/a
Temperature310.15±n/a K
Ki 2100±n/a nM
Citation Bello AMPoduch ELiu YWei LCrandall IWang XDyanand CKain KCPai EFKotra LP Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase. J Med Chem 51:439-48 (2008) [PubMed]  Article
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Orotidine Monophosphate Decarboxylase (ODCase)
Name:Orotidine Monophosphate Decarboxylase (ODCase)
Synonyms:ODCase | Orotidine 5-Phosphate Decarboxylase
Type:Enzyme
Mol. Mass.:37826.43
Organism:Plasmodium falciparum (malaria parasite P. falciparum)
Description:n/a
Residue:323
Sequence:
MGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNNIKKNLKEKYINNVSIKK
DILLKAPDNIIREEKSEEFFYFFNHFCFYIINETNKYALTFKMNFAFYIPYGSVGIDVLK
NVFDYLYELNIPTILDMKINDIGNTVKNYRKFIFEYLKSDSCTVNIYMGTNMLKDICYDE
EKNKYYSAFVLVKTTNPDSAIFQKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFV
VGANSYDEMNYIRTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIGRAITKNP
YPQKAAQMYYDQINAILKQNMES
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BDBM21338
NameBDBM21338
Synonyms:6-Amino-uridine 5-O-Monophosphate | C6-Uridine Derivative, 15 | JMC521648 Compound 37 | {[(2R,3S,4R,5R)-5-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
TypeSmall organic molecule
Emp. Form.C9H14N3O9P
Mol. Mass.339.1959
SMILESNc1cc(=O)[nH]c(=O)n1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure
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BDBM21336
NameBDBM21336
Synonyms:3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | OMP | orotidine 5-monophosphate | orotidylic acid
TypeNucleoside or nucleotide
Emp. Form.C10H13N2O11P
Mol. Mass.368.1908
SMILESO[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(cc(=O)[nH]c1=O)C(O)=O |r|
Structure
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