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TargetDihydroorotate Dehydrogenase (DHODH)
LigandBDBM16114
Substrate/CompetitorBDBM16110
Meas. Tech.DHODH Inhibition Assay
pH8±n/a
Temperature298.15±n/a K
IC50 44±n/a nM
Citation Leban JKralik MMies JBaumgartner RGassen MTasler S Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors. Bioorg Med Chem Lett 16:267-70 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dihydroorotate Dehydrogenase (DHODH)
Name:Dihydroorotate Dehydrogenase (DHODH)
Synonyms:DHOdehase | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase
Type:Enzyme
Mol. Mass.:39810.15
Organism:Homo sapiens (human)
Description:Recombinant human DHODH (amino acids 30 to 396) was cloned and expressed in E. coli.
Residue:367
Sequence:
MATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFR
NPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGF
NSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYL
VVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIA
SVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVP
IIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDA
IGADHRR
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BDBM16114
NameBDBM16114
Synonyms:3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}thiophene-2-carboxylic acid | Biphenyl-4-ylcarbamoyl Thiophene Analog 5 | Compound 6
TypeSmall organic molecule
Emp. Form.C19H14FNO4S
Mol. Mass.371.382
SMILESCOc1cccc(c1)-c1ccc(NC(=O)c2ccsc2C(O)=O)c(F)c1
Structure
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BDBM16110
NameBDBM16110
Synonyms:2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione | 2-[(2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaenyl]-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione | Coenzyme Q6 | Ubiquinone 6
Typen/a
Emp. Form.C39H58O4
Mol. Mass.590.8754
SMILES[#6]-[#8]-[#6]-1=[#6](-[#8]-[#6])-[#6](=O)-[#6](-[#6]-[#6]=[#6](-[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])=[#6](-[#6])-[#6]-1=O |w:10.9,c:2,t:38|
Structure
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