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PDB code 3U8D

Compile Data Set for Download or QSAR

Identical Ligands in BindingDB

Found 6 hits Enzyme Inhibition Constant Data   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phospholipase A2, membrane associated

  (124/124 = 100%)
(Homo sapiens (human))
BDBM23771
PNG
((3-{[1-benzyl-3-(carbamoylmethyl)-2-ethyl-1H-indol...)
Show SMILES CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)
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n/an/a 23n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human non-pancreatic secretory phospholipase A2 (PLA2) in a chromogenic assay


J Med Chem 39: 5137-58 (1997)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phospholipase A2, membrane associated

  (124/124 = 100%)
(Homo sapiens (human))
BDBM23771
PNG
((3-{[1-benzyl-3-(carbamoylmethyl)-2-ethyl-1H-indol...)
Show SMILES CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)
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n/an/a 470n/an/an/an/a7.522



Universite Paris 7-Denis Diderot



Assay Description
PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...


Bioorg Med Chem 16: 1242-53 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phospholipase A2, membrane associated

  (124/124 = 100%)
(Homo sapiens (human))
BDBM23771
PNG
((3-{[1-benzyl-3-(carbamoylmethyl)-2-ethyl-1H-indol...)
Show SMILES CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)
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n/an/a 470n/an/an/an/an/an/a



Universit£ Paris Diderot

Curated by ChEMBL


Assay Description
Inhibition of human recombinant group 2A phospholipase A2 by fluorimetric assay


Bioorg Med Chem 18: 3588-600 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phospholipase A2, membrane associated

  (124/124 = 100%)
(Homo sapiens (human))
BDBM23771
PNG
((3-{[1-benzyl-3-(carbamoylmethyl)-2-ethyl-1H-indol...)
Show SMILES CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)
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PubMed
n/an/a 470n/an/an/an/an/an/a



Université Paris7-Denis Diderot

Curated by ChEMBL


Assay Description
Inhibition of human group IIA PLA2 by fluorimetric assay


J Med Chem 50: 1618-26 (2007)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phospholipase A2, membrane associated

  (124/124 = 100%)
(Homo sapiens (human))
BDBM23771
PNG
((3-{[1-benzyl-3-(carbamoylmethyl)-2-ethyl-1H-indol...)
Show SMILES CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)
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n/an/a 3.55E+4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine pancreatic Phospholipase A2


J Med Chem 39: 5137-58 (1997)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phospholipase A2, membrane associated

  (124/124 = 100%)
(Homo sapiens (human))
BDBM23771
PNG
((3-{[1-benzyl-3-(carbamoylmethyl)-2-ethyl-1H-indol...)
Show SMILES CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)
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n/an/a 9.11E+4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human pancreatic Phospholipase A2


J Med Chem 39: 5137-58 (1997)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)

Search BindingMOAD for More Affinity Data:

* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
Identities from BLAST output