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PDB code 2P99

Compile Data Set for Download or QSAR

Identical Ligands in BindingDB

Found 9 hits Enzyme Inhibition Constant Data   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase (MAP)

  (261/261 = 100%)
(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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CHEMBL
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PubMed
n/an/a 1.16E+3n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 5 uM Manganese


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)

  (261/261 = 100%)
(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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CHEMBL
DrugBank
PC cid
PC sid
PDB
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Article
PubMed
n/an/a 5.78E+3n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Ni(II) form of Escherichia coli MetAP


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)

  (261/261 = 100%)
(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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CHEMBL
DrugBank
PC cid
PC sid
PDB
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PDB
Article
PubMed
n/an/a 5.78E+3n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 10 uM Nickel


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)

  (261/261 = 100%)
(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

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CHEMBL
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PC cid
PC sid
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PubMed
n/an/a 6.56E+3n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 100 uM Manganese


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)

  (261/261 = 100%)
(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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CHEMBL
DrugBank
PC cid
PC sid
PDB
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PDB
Article
PubMed
n/an/a 6.56E+3n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Mn(II) form of Escherichia coli MetAP


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)

  (261/261 = 100%)
(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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GoogleScholar
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CHEMBL
DrugBank
PC cid
PC sid
PDB
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PDB
Article
PubMed
n/an/a 5.80E+4n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Fe(II) form of Escherichia coli MetAP


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)

  (261/261 = 100%)
(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
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CHEMBL
DrugBank
PC cid
PC sid
PDB
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PDB
Article
PubMed
n/an/a 5.80E+4n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 6 uM Iron


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)

  (261/261 = 100%)
(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

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PDB
Article
PubMed
n/an/a 7.71E+4n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Co(II) form of Escherichia coli MetAP


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)

  (261/261 = 100%)
(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
DrugBank
PDB
Article
PubMed
n/an/a 7.71E+4n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 100 uM Cobalt


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)

Search BindingMOAD for More Affinity Data:

* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
Identities from BLAST output