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9 similar compounds to monomer 50204625

Wt: 678.7
BDBM50204622
Wt: 414.4
BDBM50204623
Wt: 866.0
BDBM50204624
Wt: 520.5
BDBM50204626
Wt: 514.5
BDBM50204628
Wt: 578.6
BDBM50204629
Wt: 462.5
BDBM50249958
Wt: 404.4
BDBM50249959
Wt: 448.5
BDBM50249885

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50204622,50204623,50204624,50204626,50204628,50204629,50249958,50249959,50249885   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C delta type


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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2.70n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCdelta in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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4.10n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCbeta in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50204623
PNG
(CHEMBL223747 | [2-(hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(cc2)C#C)[#8]-[#6]-1=O
Show InChI InChI=1/C26H22O5/c1-4-19-5-7-20(8-6-19)9-10-21-11-13-22(14-12-21)24(28)30-17-26(16-27)15-23(18(2)3)25(29)31-26/h1,5-8,11-14,27H,15-17H2,2-3H3
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5.20n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from PKCalpha


J Med Chem 50: 962-78 (2007)

More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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5.40n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCdelta in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50204626
PNG
((2-(hydroxymethyl)-5-oxo-4-(propan-2-ylidene)-tetr...)
Show SMILES [#6]-[#8]-c1ccc(cc1)C#Cc1ccc(cc1)C#Cc1ccc(cc1)-[#6](=O)-[#8]-[#6]C1([#6]-[#8])[#6]\[#6](=[#6](/[#6])-[#6])-[#6](=O)-[#8]1
Show InChI InChI=1/C33H28O6/c1-23(2)30-20-33(21-34,39-32(30)36)22-38-31(35)28-16-12-26(13-17-28)10-8-24-4-6-25(7-5-24)9-11-27-14-18-29(37-3)19-15-27/h4-7,12-19,34H,20-22H2,1-3H3
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5.90n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from PKCalpha


J Med Chem 50: 962-78 (2007)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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6n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCalpha in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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6.20n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCgamma in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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8.30n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCepsilon in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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10n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCepsilon in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50204628
PNG
(CHEMBL223570 | [2-(hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(cc2)C#Cc2ccc(cc2)C#C)[#8]-[#6]-1=O
Show InChI InChI=1/C34H26O5/c1-4-25-5-7-26(8-6-25)9-10-27-11-13-28(14-12-27)15-16-29-17-19-30(20-18-29)32(36)38-23-34(22-35)21-31(24(2)3)33(37)39-34/h1,5-8,11-14,17-20,35H,21-23H2,2-3H3
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12n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from PKCalpha


J Med Chem 50: 962-78 (2007)

More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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12n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCgamma in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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12n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCdelta in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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12n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCdelta in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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13n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCbeta in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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15n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCbeta in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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16n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCalpha in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50204629
PNG
(CHEMBL221289 | methyl 2-{4-[2-(4-{2-[4-({[2-(hydro...)
Show SMILES [#6]-[#8]-[#6](=O)-[#6]-[#8]-c1ccc(cc1)C#Cc1ccc(cc1)C#Cc1ccc(cc1)-[#6](=O)-[#8]-[#6]C1([#6]-[#8])[#6]\[#6](=[#6](/[#6])-[#6])-[#6](=O)-[#8]1
Show InChI InChI=1/C35H30O8/c1-24(2)31-20-35(22-36,43-34(31)39)23-42-33(38)29-16-12-27(13-17-29)10-8-25-4-6-26(7-5-25)9-11-28-14-18-30(19-15-28)41-21-32(37)40-3/h4-7,12-19,36H,20-23H2,1-3H3
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16n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from PKCalpha


J Med Chem 50: 962-78 (2007)

More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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16n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCgamma in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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20n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCalpha in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
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21n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCalpha in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
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31n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCdelta in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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32n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCepsilon in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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32n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCgamma in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
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35n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCgamma in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
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36n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCdelta in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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38n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCepsilon in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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44n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCbeta in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
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57n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCbeta in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
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66n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCbeta in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249958
PNG
(CHEMBL489520 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C28H30O6/c1-20(2)25-17-28(18-29,34-27(25)31)19-33-26(30)5-4-16-32-24-14-12-23(13-15-24)11-10-22-8-6-21(3)7-9-22/h6-9,12-15,29H,4-5,16-19H2,1-3H3
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76n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCalpha in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
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78n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCgamma in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
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79n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCepsilon in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50204624
PNG
(CHEMBL220099 | tert-butyl 2-({[(tert-Butyl)oxycarb...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-c2ccc(cc2)C#Cc2ccc(cc2)C#Cc2ccc(-[#8]-[#6]-[#6]-[#8]-[#6]-[#6]-[#8]-[#6]-[#6]-[#7](-[#6]-[#6](=O)-[#8]C([#6])([#6])[#6])-[#6]-[#6](=O)-[#8]C([#6])([#6])[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C50H59NO12/c1-36(2)43-31-50(34-52,63-47(43)56)35-60-46(55)41-21-17-39(18-22-41)15-13-37-9-11-38(12-10-37)14-16-40-19-23-42(24-20-40)59-30-29-58-28-27-57-26-25-51(32-44(53)61-48(3,4)5)33-45(54)62-49(6,7)8/h9-12,17-24,52H,25-35H2,1-8H3
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111n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from PKCalpha


J Med Chem 50: 962-78 (2007)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50204622
PNG
(CHEMBL221290 | methyl 2-[4-(2-{4-[2-(4-{2-[4-({[2-...)
Show SMILES [#6]-[#8]-[#6](=O)-[#6]-[#8]-c1ccc(cc1)C#Cc1ccc(cc1)C#Cc1ccc(cc1)C#Cc1ccc(cc1)-[#6](=O)-[#8]-[#6]C1([#6]-[#8])[#6]\[#6](=[#6](/[#6])-[#6])-[#6](=O)-[#8]1
Show InChI InChI=1/C43H34O8/c1-30(2)39-26-43(28-44,51-42(39)47)29-50-41(46)37-22-18-35(19-23-37)16-14-33-10-6-31(7-11-33)4-5-32-8-12-34(13-9-32)15-17-36-20-24-38(25-21-36)49-27-40(45)48-3/h6-13,18-25,44H,26-29H2,1-3H3
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127n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from PKCalpha


J Med Chem 50: 962-78 (2007)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
PDB
MMDB

NCI pathway
SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
143n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCalpha in presence of plasma membrane lipid mimetic mixture


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50249885
PNG
(CHEMBL492118 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES [#6]\[#6](-[#6])=[#6]-1/[#6]C([#6]-[#8])([#6]-[#8]-[#6](=O)-[#6]-[#6]-[#8]-c2ccc(cc2)C#Cc2ccc(-[#6])cc2)[#8]-[#6]-1=O
Show InChI InChI=1/C27H28O6/c1-19(2)24-16-27(17-28,33-26(24)30)18-32-25(29)14-15-31-23-12-10-22(11-13-23)9-8-21-6-4-20(3)5-7-21/h4-7,10-13,28H,14-18H2,1-3H3
PDB
MMDB

NCI pathway
Reactome pathway
SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
153n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCepsilon in presence of phosphatidylserine


J Med Chem 52: 3274-83 (2009)

More data for this
Ligand-Target Pair