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BDBM50323722 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate::4-fluorophenyl 3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoate::CHEMBL1213031

SMILES: Cc1cc(\C=C\c2cccc(c2)C(=O)Oc2ccc(F)cc2)cc(C)c1O

InChI Key: InChIKey=YDSMVVNYVJZDET-VOTSOKGWSA-N

Data: 1 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50323722   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transthyretin (TTR)


(Homo sapiens (Human))
BDBM50323722
PNG
(4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)ben...)
Show SMILES Cc1cc(\C=C\c2cccc(c2)C(=O)Oc2ccc(F)cc2)cc(C)c1O
Show InChI InChI=1S/C23H19FO3/c1-15-12-18(13-16(2)22(15)25)7-6-17-4-3-5-19(14-17)23(26)27-21-10-8-20(24)9-11-21/h3-14,25H,1-2H3/b7-6+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem
AffyNet 
PDB
Article
PubMed
n/an/a 1.96E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...


Nat Chem Biol 6: 133-9 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)