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BDBM50303766 2-oxoglutaric acid::2-oxopentanedioic acid::CHEMBL1686::alpha-ketoglutaric acid

SMILES: OC(=O)CCC(=O)C(O)=O

InChI Key: InChIKey=KPGXRSRHYNQIFN-UHFFFAOYSA-N

Data: 2 IC50  6 Kd

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50303766   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50303766
PNG
(2-oxoglutaric acid | 2-oxopentanedioic acid | CHEM...)
Show SMILES OC(=O)CCC(=O)C(O)=O
Show InChI InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
PDB
MMDB

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Article
PubMed
n/an/an/a 1.70E+3n/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperature


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50303766
PNG
(2-oxoglutaric acid | 2-oxopentanedioic acid | CHEM...)
Show SMILES OC(=O)CCC(=O)C(O)=O
Show InChI InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
PDB
MMDB

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Article
PubMed
n/an/an/a 2.20E+3n/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperature


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50303766
PNG
(2-oxoglutaric acid | 2-oxopentanedioic acid | CHEM...)
Show SMILES OC(=O)CCC(=O)C(O)=O
Show InChI InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
PDB
MMDB

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Article
PubMed
n/an/an/a 900n/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50303766
PNG
(2-oxoglutaric acid | 2-oxopentanedioic acid | CHEM...)
Show SMILES OC(=O)CCC(=O)C(O)=O
Show InChI InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
PDB
MMDB

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Article
PubMed
n/an/an/a 900n/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by 1H-15N HSQC titration assay


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50303766
PNG
(2-oxoglutaric acid | 2-oxopentanedioic acid | CHEM...)
Show SMILES OC(=O)CCC(=O)C(O)=O
Show InChI InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
PDB
MMDB

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AffyNet 
Article
PubMed
n/an/an/a 900n/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Binding affinity to human PHD2 by nondenaturing ESI-MS


Citation and Details
More data for this
Ligand-Target Pair
Solute carrier family 22 member 2


(Rattus norvegicus)
BDBM50303766
PNG
(2-oxoglutaric acid | 2-oxopentanedioic acid | CHEM...)
Show SMILES OC(=O)CCC(=O)C(O)=O
Show InChI InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
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PubMed
n/an/a 7.00E+5n/an/an/an/an/an/a



Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes


Am J Physiol Renal Physiol 281: 454-68 (2001)

More data for this
Ligand-Target Pair
Solute carrier family 22 member 1


(Rattus norvegicus)
BDBM50303766
PNG
(2-oxoglutaric acid | 2-oxopentanedioic acid | CHEM...)
Show SMILES OC(=O)CCC(=O)C(O)=O
Show InChI InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
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CHEMBL
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AffyNet 
PubMed
n/an/a 7.40E+5n/an/an/an/an/an/a



Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t

Curated by ChEMBL


Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes


Am J Physiol Renal Physiol 281: 454-68 (2001)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50303766
PNG
(2-oxoglutaric acid | 2-oxopentanedioic acid | CHEM...)
Show SMILES OC(=O)CCC(=O)C(O)=O
Show InChI InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
PDB
MMDB

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CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
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Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a 1.00E+3n/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature in presence of HIF1alpha (55...


Citation and Details
More data for this
Ligand-Target Pair