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BDBM50264221 2-(4-hydroxy-8-iodoisoquinoline-3-carboxamido)acetic acid::CHEMBL509064::N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE

SMILES: OC(=O)CNC(=O)c1ncc2c(I)cccc2c1O

InChI Key: InChIKey=FUMNLXHPILGSLC-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50264221   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50264221
PNG
(2-(4-hydroxy-8-iodoisoquinoline-3-carboxamido)acet...)
Show SMILES OC(=O)CNC(=O)c1ncc2c(I)cccc2c1O
Show InChI InChI=1S/C12H9IN2O4/c13-8-3-1-2-6-7(8)4-14-10(11(6)18)12(19)15-5-9(16)17/h1-4,18H,5H2,(H,15,19)(H,16,17)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
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AffyNet 
CHEMBL
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MMDB
PC cid
PC sid
PDB
UniChem
AffyNet 
MMDB
PDB
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PHD2 (unknown origin) by fluorescence energy transfer analysis


Bioorg Med Chem Lett 18: 5023-6 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)