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BDBM50240802 1-N-ACETYL-BETA-D-GLUCOSAMINE::CHEMBL335315::N-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)acetamide::N-(3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-acetamide::N-acetyl-b-D-glucopyranosylamine::N-acetyl-beta-D-glucopyranosylamine

SMILES: CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

InChI Key: InChIKey=IBONACLSSOLHFU-UHKAZQGNNA-N

Data: 13 KI

PDB links: 17 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50240802   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Brain glycogen phosphorylase


(Homo sapiens)
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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Article
PubMed
3.10E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against muscle Glycogen Phosphorylase b


J Med Chem 44: 2843-8 (2001)

More data for this
Ligand-Target Pair
Muscle glycogen phosphorylase


(Homo sapiens)
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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PubMed
3.16E+4n/an/an/an/an/an/an/an/a



University of Alcala

Curated by ChEMBL


Assay Description
Inhibitory activity against rabbit muscle glycogen phosphorylase


J Med Chem 40: 4089-102 (1998)

Checked by Author
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit skeletal muscle glycogen phosphorylase b


Bioorg Med Chem 18: 1171-80 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase b assessed as inorganic phosphate release at pH 6.8


Bioorg Med Chem 20: 1801-16 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a



National Hellenic Research Foundation

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase inactive form b


Bioorg Med Chem 18: 3413-25 (2010)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Inhibition of rabbit skeletal muscle glycogen phosphorylase b assessed as inorganic phosphate release


Bioorg Med Chem 22: 4810-25 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Brain glycogen phosphorylase


(Homo sapiens)
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a



The University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibitory binding constant against glycogen phosphorylase B


J Med Chem 47: 3075-88 (2004)

More data for this
Ligand-Target Pair
Brain glycogen phosphorylase


(Homo sapiens)
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a



University of Perugia

Curated by ChEMBL


Assay Description
Inhibition of rabbit glycogen phosphorylase B enzyme


J Med Chem 40: 1455-64 (1997)

More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase b


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase b


Eur J Med Chem 76: 567-79 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase b


Bioorg Med Chem 17: 4773-85 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
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3.20E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase b


Bioorg Med Chem Lett 18: 5680-3 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Brain glycogen phosphorylase


(Homo sapiens)
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/s2
PDB

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PubMed
3.20E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibitory activity against muscle Glycogen Phosphorylase b


J Med Chem 44: 2843-8 (2001)

More data for this
Ligand-Target Pair