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BDBM26670 2,3-diphenyl-1H-indole-7-carboxylic acid::cid_5003498::diphenylindole carboxylic acid, 3

SMILES: OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1

InChI Key: InChIKey=OLUDUXWVPIEHDA-UHFFFAOYSA-N

Data: 1 KI  1 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26670   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26670
PNG
(2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...)
Show SMILES OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15NO2/c23-21(24)17-13-7-12-16-18(14-8-3-1-4-9-14)19(22-20(16)17)15-10-5-2-6-11-15/h1-13,22H,(H,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
AffyNet 
PDB
Article
PubMed
550 -8.68n/an/an/an/an/a7.630



Vertex



Assay Description
A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26670
PNG
(2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...)
Show SMILES OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15NO2/c23-21(24)17-13-7-12-16-18(14-8-3-1-4-9-14)19(22-20(16)17)15-10-5-2-6-11-15/h1-13,22H,(H,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
AffyNet 
PDB
Article
PubMed
n/an/a 550n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
streptokinase A precursor


(Streptococcus pyogenes M1 GAS)
BDBM26670
PNG
(2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...)
Show SMILES OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15NO2/c23-21(24)17-13-7-12-16-18(14-8-3-1-4-9-14)19(22-20(16)17)15-10-5-2-6-11-15/h1-13,22H,(H,23,24)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
AffyNet 
PCBioAssay
n/an/an/an/a 1.56E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair