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BDBM17716 2,3-Diarylfuro[2,3-b]pyridine-4-amine, 8::2,3-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-b]pyridin-4-amine

SMILES: C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1

InChI Key: InChIKey=QUIQCYFSBGOBKE-UHFFFAOYSA-N

Data: 4 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17716   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM17716
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 8 | 2,3-dip...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-3-7-19(8-4-1)22-23-21(27-15-18-29-16-13-26-14-17-29)11-12-28-25(23)30-24(22)20-9-5-2-6-10-20/h1-12,26H,13-18H2,(H,27,28)
PDB
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PC cid
PC sid
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Article
PubMed
n/an/a 360n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


Bioorg Med Chem Lett 17: 2299-304 (2007)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM17716
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 8 | 2,3-dip...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-3-7-19(8-4-1)22-23-21(27-15-18-29-16-13-26-14-17-29)11-12-28-25(23)30-24(22)20-9-5-2-6-10-20/h1-12,26H,13-18H2,(H,27,28)
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PC cid
PC sid
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UniChem

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AffyNet 
Article
PubMed
n/an/a 140n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


Bioorg Med Chem Lett 17: 2299-304 (2007)

More data for this
Ligand-Target Pair
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM17716
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 8 | 2,3-dip...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-3-7-19(8-4-1)22-23-21(27-15-18-29-16-13-26-14-17-29)11-12-28-25(23)30-24(22)20-9-5-2-6-10-20/h1-12,26H,13-18H2,(H,27,28)
PDB
MMDB

SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 420n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


Bioorg Med Chem Lett 17: 2299-304 (2007)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM17716
PNG
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 8 | 2,3-dip...)
Show SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-3-7-19(8-4-1)22-23-21(27-15-18-29-16-13-26-14-17-29)11-12-28-25(23)30-24(22)20-9-5-2-6-10-20/h1-12,26H,13-18H2,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
SMPDB pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
Article
PubMed
n/an/a 210n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


Bioorg Med Chem Lett 17: 2299-304 (2007)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)